Endocrine Abstracts

Pancreatic neuroendocrine tumors constitute a disease with steadily increasing prevalence worldwide in part owing to the increased detection of early stage disease. Here we present the case of a 49 year old male patient, who was admitted with clinical, laboratory and CT features of acute pancreatitis. A clear cause for the pancreatitis could not be detected. Excessive alcohol intake was reliably denied, and the patient did not take any drugs. Gallbladder and bile ducts were in...

Fluid and electrolyte disturbances are a challenging problem of inpatients, especially in those subpopulations, in whom the electrolyte imbalance is involved in the pathogenesis of the primary disease. Here we present the case of a 58 year old woman, with ongoing alcohol abuse on a daily basis, who was admitted with progressive fatigue and dysphagia. At the admission BMI was 17.8 kg/m2, and the patient presented deficiency of vitamins A, B, and D. The diagnostic pro...

Introduction: Irisin is a newly discovered adipo-myokine, that has a significant influence on body metabolism. Available data about this peptide is still insufficient. The aim of the study is to provide some initial information about body distribution of irisin in rats.Methods: The studied group consisted of 27 10-week-old female Wistar rats, which received intraperitoneally ~0.7 mcCi of iodine-125 labeled irisin. The studied rats were divided on five su...

We have earlier shown that treatment with gonadotropin releasing hormone antagonist blocked adrenocortical tumour progression through gonadotropin suppression in inhibin α/SV40 T-antigen (inhα/Tag) transgenic (TG) mice. Hereby, we investigated the molecular mechanisms underlying the GnRH antagonist (Cetrorelix acetate; GnRH-a) treatment induced potential antitumor effects on gonadal somatic cell and adrenocortical tumors in vivo and in vitro. In...

Pituitary tumor is a rare endocrine disorder. In the majority of cases, they are secreting prolactin and/or GH. Pituitary metastatic tumors are localized more often in the nervous than adenomatous hypophysis. Lung, breast and large intestine cancers metastases are found in the pituitary in the most cases. They cause hypopituitarism and local complications. The most often complications found are an optic nerve chiasm pressure or infiltration with a visual field loss, cavernous ...

Leptin, adiponectin and resistin play an essential role in regulation of body mass, which is controlled by thyroid hormones levels.The aim of the study was to evaluate leptin, adiponectin and resistin levels in young patients with Graves’ disease and in children with Hashimoto’s thyroiditis.The study group formed 78 patients suffering from Graves’ disease (30 girls and 2 boys; aged from 6 to 21- mean 15.2 years) and ...

Adrenocortical carcinoma (ACC) is a rare neoplasm with poor prognosis. Patients can present signs of hormone excess: virilisation, Cusging’s syndrome or only enlarged abdominal mass. Incidentally ACC can be also detected in the ultrasonography. Some of ‘non-hypersecretory’ ACCs can produce non-bioactive hormones steroid precursors or not very big amount of them and sometimes patients present subclinical Cushing’s symptoms. Surgery and adjuvant radiotherapy ...

Introduction: Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes, combined together, under the name of MELAS syndrome, constitute one of the mitochondrial genetic diseases with dominant progressive neurodegenerative symptoms. Although nervous system involvement is often the first manifestation of the disease, during the course of the disorder, patient can develop a wide spectrum of endocrine disorders ranging from GH deficiency and hypoparathyroi...

Introduction: While searching for mechanisms contributing to the increased mortality of acromegaly, we have previously described an unexpected sympathoinhibition in newly diagnosed patients (Seravalle et al., Clin Endocrinol 77:262, 2012) and interpreted this finding as an adaptive phenomenon. It has also been shown that centrally administered somatostatin (SS) inhibits peripheral sympathetic outflow in rodents (Rettig et al., Am J Physiol 257:R588, 1989). Ba...

By direct measurement of muscle sympathetic nerve activity (MSNA) we previously demonstrated a markedly decreased adrenergic tone in newly diagnosed acromegalic patients. The present study was aimed at confirming this finding in a larger group of patients and establishing the pathophysiological role of insulin resistance, GH and IGF1 levels, circulating leptin and extracellular water (ECW) in this abnormality.Study design: Fifteen de novo patients...